Zohreh Ebrahimnezhad, Nosratollah Zarghami*, Manoutchehr Keyhani, Soumaye Amirsaadat, Abolfazl Akbarzadeh, Mohammad Rahmati, Zohreh Mohammad Taheri, Kazem Nejati-Koshki
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Umamaheswaran Gurusamy*, Steven Aibor Dkhar, Arun Kumar Annan Sudarsan, Katiboina Srinivasa Rao, Dharanipragada Kadambari, Chandrasekaran Adithan
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Babak Nami*  , Armin Ghasemi-Dizgah, Akbar Vaseghi
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Mohammad-Hossein Biglu*, Parvaneh Abotalebi, Mostafa Ghavami*
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Muhammad Nuh Musa, Sheba Rani David* , Ihsan Nazurah Zulkipli , Abdul Hanif Mahadi, Srikumar Chakravarthi, Rajan Rajabalaya*
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Hassan Moghtaderi, Houri Sepehri*, Ladan Delphi, Farnoosh Attari
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Ayuob Aghanejad, Hiwa Babamiri, Khosro Adibkia, Jaleh Barar , Yadollah Omidi*
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Sepideh Parvizpour, Jafar Razmara, Mohammad M. Pourseif, Yadollah Omidi*
Using
immunoinformatic tools, a multi-epitope peptide vaccine (consisting of CD8+cytotoxic T lymphocytes epitopes, helper epitopes and
adjuvant) was designed to combat the triple-negative breast cancer. The vaccine
showed acceptable immunogenicity and potential to stimulate both cellular and
humoral immune responses.
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Mohammad Reza Asgharzadeh, Mohammad M. Pourseif, Jaleh Barar , Morteza Eskandani, Mojtaba Jafari Niya, Mohammad Reza Mashayekhi, Yadollah Omidi*
Increased expression of TSGA10 associated with the reduced metastasis in the MDA-MB-231 cells. TSGA10 showed interaction with HIF-1α with high affinity. TSGA10 expression is altered under the hypoxia, indicating its potential as a bio-target for cancer therapy.
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Fatemeh Abedi Jafari , Asghar Abdoli* , Reza Pilehchian, Neda Soleimani, Seyed Masoud Hosseini
The experiment concluded that the C. novyi nontoxic might be a suitable and safe candidate, a novel therapeutic approach to encounter such hypoxic regions in the center of tumors
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Amir Shakouri , Houman Kahroba, Hamed Hamishekar, Jalal Abdolalizadeh*
In the first stage of the procedure, medical leech saliva was extracted and for encapsulating these proteins, liposome technique was applied. Continually, nano drug applied on cancer cells and expression of genes were evaluated by Real- Time PCR and western blotting.
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Javad Firouzi , Fattah Sotoodehnejadnematalahi, Alireza Shokouhifar , Mahsa Rahimi, Niloufar Sodeifi, Parisa Sahranavardfar, Masoumeh Azimi, Ehsan Janzamin, Majid Safa, Marzieh Ebrahimi*
The effect of silibinin evaluated on self-renewal, tumorgenicity, and metastasis potential of Mammospheres derived from MCF-7, MDA-MB231 cell lines, and MDA-MB468 aggregated cells
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Laura Cabeza , Mazen M. El-Hammadi , Raul Ortiz , Maria D. Cayero-Otero, Julia Jiménez-López , Gloria Perazzoli , Lucia Martin-Banderas , Jose M. Baeyens , Consolación Melguizo* , Jose Prados
These results suggest that our PTX-PLGA NPs could be a suitable strategy for breast cancer therapy, improving antitumor drug efficiency and reducing systemic toxicity without altering its mechanism of action.
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Nasrollah Jabbari , Maryam Feghhi, Omid Esnaashari, Hamid Soraya, Jafar Rezaie*
Treatment of MCF-10a, MCF-7, and MDA-MD-231 cells with Gallic acid resulted in inhibition in the activity of the exosomal secretory pathway. Gallic acid can decrease the expression of genes involved in exosomes biogenesis (Alix and CD63) and secretion (Rab proteins). In addition, Gallic acid can change the expression of autophagy markers (LC3 and P62) in these cells. MVB: multivesicular body.
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Raghdah S. Bawadud , Mayson H. Alkhatib*
Co-delivery of NE-DTX+TQ may probably inhibit the proliferation of T47D via the induction of apoptosis and autophagy pathways and impede the migration by reducing the BCSC population and downregulating TWIST-1 expression to decrease the epithelial-to-mesenchymal transition (EMT) of breast cancer cells
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Behnaz Babaye Abdollahi , Marjan Ghorbani, Hamed Hamishehkar, Reza Malekzadeh, Alireza Farajollahi*
This study shows the positive effect of synthesized Trastuzumab loaded PEG-Fe3O4@Au nanoparticleson increasing the death rate of Breast cancer cells during megavoltage radiation therapy.
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Yuri Yu. Shchegolev , Danila V. Sorokin, Alexander M. Scherbakov* , Olga E. Andreeva , Diana I. Salnikova , Ekaterina I. Mikhaevich , Margarita V. Gudkova , Mikhail A. Krasil’nikov
Prolonged cell treatment with mTOR inhibitor rapamycin leads to the development of resistance. Exosomes of resistant cells induce the resistance to rapamycin in the parent MCF-7cells. Exosome-induced resistance reproduces the changes revealed in the rapamycin-resistant cells, including the activation of ERK/AP-1.
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Nazila Jalilzadeh , Neda Barzgar Barough, Mehrdad Karami, Amir Baghbanzadeh, Kobra Velaei*
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Havva Afshari , Shokoofe Noori* , Mitra Nourbakhsh, Azam Daraei, Mahsa Azami Movahed, Afshin Zarghi
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Zeinab Mazloumi , Ali Rafat, Khadijeh Dizaji Asl, Mohammad Karimipour, Dariush Shanehbandi, Mehdi Talebi, Majid Montazer, Ali Akbar Movassaghpour, Alireza Dehnad, Raheleh Farahzadi, Hojjatollah Nozad Charoudeh*
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Zahra Alidoost , Farnoosh Attari* , Fatemeh Saadatpour, Ehsan Arefian
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Snehal Aditya Arvindekar* , Sanket Rathod , Prafulla Balkrishna Choudhari , Pradnya Kiran Mane , Aditya Umesh Arvindekar* , Suraj Narayan Mali , Bapu Thorat
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Hamed Zare , Hamid Bakherad* , Arman Nasr Esfahani, Mohamad Norouzi, Hossein Aghamollaei, Seyed Latif Mousavi Gargari, Fatemeh Mahmoodi, Mahdi Aliomrani, Walead Ebrahimizadeh
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